You only need to disable the resident feature of Spybot-S&D. And that is the way to deactivate it: Run Spybot-S&D, switch to the Advanced mode via the menu bar item Mode → hit Yes → select Tools in the navigation bar on the left → Resident and there you can untick the checkboxes in front of the two tools.

But warning! Then you will not have resident protection!

See animated flash tutorial (443kb)

Hide screenshot